• About
  • People
  • Funding
  • Student Awards
  • Community Engagement

Our primary research interest is Breast Cancer and Bone Metastasis as breast cancer is the most common cancer in women that metastasises to bone. Despite recent advances, our knowledge of why bone is such a fertile “soil” for tumour cells to home in on remains poor. Our research aims to provide vigorous preclinical data that will facilitate the translation of novel therapeutics to clinical trials for bone metastases.

We have identified a novel method of treating both cancer progression and metastasis, by targeting the body’s natural immune response. Myeloperoxidase (MPO) and eosinophil peroxidase (EPO), well known for their antimicrobial activity, are released in high quantities by infiltrating immune cells in a variety of tumour types, including breast cancer. Our laboratory has shown for the first time that peroxidases are causatively involved in modulating the cancer microenvironment to promote blood vessel development and extracellular matrix biosynthesis. These processes are major hallmarks in cancer progression and as such identify peroxidases as drugable targets for cancer therapy.

Researchers

Students

Student Alumni (since 2016)

NameDegreeYear AwardedThesis titleSupervisorsScholarship
Kyle BrewerHonours (1st class), University of Adelaide2017Injectable thermoresponsive hydrogels for adoptive cell therapiesEvdokiou A and Blencowe A (UniSA)The Hospital Research Foundation Honours Scholarship
Vasilios (Bill) LiapisPhD, University of Adelaide2017Targeting cancer in the bone with the hypoxia activated pro-drug EvofosfamideEvdokiou A, De Nichilo M & Zinonos IFaculty of Health Sciences Divisional Scholarship, plus Department of Surgery supplementary scholarship, University of Adelaide
Aneta ZyskPhD, University of Adelaide2017Adoptive transfer of ex vivo expanded gamma delta T cells targeting osteolytic cancer in the boneEvdokiou A and De Nichilo MAustralian Postgraduate Award
Vasilios (Bill) PanagopoulosPhD, University of Adelaide2016A novel role for peroxidases in breast cancer development progression and metastasisEvdokiou A & De Nichilo MFaculty of Health Sciences Divisional Scholarship, plus Department of Surgery supplementary scholarship, University of Adelaide

Funding since 2015

Chief InvestigatorsGranting BodyProject TitleType of GrantTotal Grant AmountFunding Period
Evdokiou A, Atkins GJProject Grant$456,0002013 - 2015
Evdokiou AAdelaide Research and innovation (ARI)Using peroxidase enzymes to accelerate fracture repair in healthy or osteoporotic bone$85,0002014 - 2015
Evdokiou AThe Hospital Research FoundationUncovering a new role of peroxidase enzymes as drivers of mammographic density and breast cancer$150,0002015 - 2016
Evdokiou AUniversity of Adelaide DVCR$25,0002015
Evdokiou AOncolyze Inc NY, USA, Anticancer efficacy of PNC-27Commercial open grant$30,0002015 - 2016
Foreman A, Evdokiou AGarnett Passe and Rodney Williams FoundationTumour-associated microbiota and its role in oral cavity cancer carcinogenesisConjoint$375,0002016 - 2018
Evdokiou AThe Hospital Research FoundationMichell-McGrath Breast Cancer Research FellowshipFellowship$750,0002016 - 2019
Evdokiou A, Zannetino A, Blencowe AThe Hospital Research FoundationLocalized treatment of solid tumours with cytotoxic gd T cellsProject Grant$125,0002017 - 2018
Ingman W, Evdokiou A, Wrin JThe Hospital Research FoundationBreaking immune tolerance in triple negative breast cancerProject Grant$125,0002017 - 2018
Panagopoulos VThe Hospital Research FoundationTargeted inhibition of inflammatory peroxidases, a new therapeutic strategy against breast cancer and metastatic diseaseEarly Career Fellow$240,0002017 - 2019
Townsend A, Hardingham J, Tomita Y, Yool A, Price T, Evdokiou AThe Hospital Research FoundationPreclinical investigation of the efficacy of novel aquaporin inhibitors in preventing growth and metastasis of breast cancerABCR Elcombe Preclinical Project Grant$255,0002017 - 2020
Sallustio BC, Evdokiou A, Horowitz JDThe Hospital Research FoundationVivid Iq Premium, Rodent Echocardiography SystemJoint equipment funding with The University of Adelaide$77,6002018
Evdokiou A, Panagopoulos VTour de CureLocalised treatment of solid tumours with cytotoxic gd T cellsProject Grant$125,0002018
Evdokiou AThe University of AdelaideLocalised treatment of solid tumours with cytotoxic gd T cellsProject Grant$50,0002018
Sallustio B, Evdokiou A, Horowitz JDNational Health & Medical Research Council (NHMRC #1145776)Prevention of heart damage during Anthracycline cancer chemotherapyProject Grant $327,2142018 - 2020
Evdokiou AFaculty of Health and Medical Sciences, The University of AdelaideNew immunotherapeutic approaches targeting incompletely resected or inoperable tumoursLeverage support for THRF project grant$75,0002018 - 2021
Evdokiou A, Zinonos IThe Hospital Research FoundationNew immunotherapeutic approaches targeting incompletely resected or inoperable tumoursProject Grant$225,0002018 - 2021
Panagopoulos VNHMRC (#1160000)Stromal cell-derived factor Gremlin 1 promotes tumour growth and metastasis of breast cancerPeter Doherty Biomedical ECR Fellowship$327,1922019 - 2022

ABCR Grant to Beat Breast Cancer

 

2015 Student Awards

NameTitle of Award & OccasionDate of AwardPresentation TitleAmount Awarded
Aneta ZyskBest Senior PhD Oral Presentation (Laboratory), TQEH Research Day16 October 2015Targeting osteosarcoma with adoptive transfer of ex vivo expanded cytotoxic gamma delta T cells in combination with zoledronic acid$1000
Alexandra ShoubridgeFlorey Medical Research Foundation Poster Presentation Prize, Faculty of Health Sciences Florey International Postgraduate Research Conference, University of Adelaide24 September 2015
Peroxidases and their role in promoting bone repair and regeneration
$300
Alexandra ShoubridgeAdelaide Research and Innovation Prize, Faculty of Health Sciences Florey International Postgraduate Research Conference, University of Adelaide24 September 2015Peroxidases and their role in promoting bone repair and regeneration$500
Vasilios (Bill) LiapisPoster Prize, Australian Society of Medical Research (ASMR SA Branch) 3 June 2015 Anticancer efficacy of the hypoxia activated prodrug TH-302 in osteolytic breast cancer murine models.$300
Vasilios (Bill) Liapis Best Junior PhD Oral Presentation (Laboratory), TQEH Research Day16 October 2015Anticancer efficacy of the hypoxia activated prodrug TH-302 in osteolytic breast cancer murine models.$1000
Vasilios (Bill) LiapisJohn Barker Prize, Faculty of Health Sciences Florey International Postgraduate Research Conference, University of Adelaide24 September 2015
Anticancer efficacy of the hypoxia activated prodrug TH-302 in osteolytic breast cancer murine models.
$300
Vasilios (Bill) PanagopoulosFlorey Medical Research Foundation Prize, Faculty of Health Sciences Florey International Postgraduate Research Conference, University of Adelaide24 September 2015 A new role for inflammatory peroxidases in breast cancer development and metastasis$700

2015 Community Engagement activities

     
Name of PresenterOrganisationDateTopicMedia format
Christopher DeFeliceAustralian Breast Cancer Research (ABCR)10 March 2015Breast cancer and fibrosisABCR newsletter and website story
Dr Mark DeNichiloSandra Kanellos FundraiserAugust 2015Advances in Breast Cancer ResearchPublic talk
Dr Mark DeNichiloGreenock CharterMay 2015Breast Cancer Research at the BHITHRF Community Awareness Presentation
Dr Mark DeNichiloBHI public tourOctober 2015Breast Cancer Research at the BHITHRF Community Awareness Presentation
Aneta ZyskRosewater Football ClubApril 2015Breast Cancer Research at the BHITHRF Community Awareness Presentation
Aneta ZyskScience Alive! 2015 assistant at BHI standAugust 2015Research at the BHIGeneral public
Aneta ZyskBasil Hetzel Society Members LuncheonNovember 2015Research at the BHITHRF Community Engagement
Dr Irene ZinonosCoast FMMay 2015The Longest Table (Ambassador for THRF fundraising campaign)Radio interview with David Hern
Dr Irene ZinonosBasil Hetzel Institute Staff and Family MembersJune 2015The Longest Table (Ambassador for THRF fundraising campaign)Hosted a fundraising dinner
Maddison ArcherAustralian Breast Cancer Research (ABCR)1 September 2015Link between breast density and cancer riskABCR newsletter & website story
Vasilios (Bill) LiapisCoast FM 17 June 2015Targeting Cancer in the boneRadio interview with David Hern
Vasilios (Bill) LiapisAustralian Breast Cancer Research (ABCR)2 September 2015New hope for breast cancers spread to the boneABCR newsletter & website story
Vasilios (Bill) PanagopoulosAustralian Breast Cancer Research (ABCR)2 December 2015Breast cancer research finds new functions for old enzymesABCR newsletter & website story