The Surgical Science Research Group is led by Professor Guy Maddern, the RP Jepson Professor of Surgery at the University of Adelaide and the Director of Research at the Basil Hetzel Institute for Translational Health Research (BHI), The Queen Elizabeth Hospital (TQEH).
Our group are always looking for enthusiastic students who wish to challenge themselves and further their education through our Honours or higher degrees programs.
Student Alumni (since 2016)
|Name||Degree||Year Awarded||Thesis title||Supervisors||Scholarship|
|Dr Hannah Gostlow||MPhil (Surgery), The University of Adelaide||2018||Simulation in surgical education: lessons learned from a multi-site randomised cohort study||Maddern GJ||Royal Australasian College of Surgeons Scholarship|
|Joseph Smith||PhD, The University of Adelaide||2018||Surgery and climate change: The scientific and public policy implications||Maddern GJ, Hewett P||Royal Australasian College of Surgeons Scholarship|
|Helen Palethorpe||PhD, The University of Adelaide||2018, Dean's Commendation for Doctoral Thesis Excellence||The regulation of tumour cell behaviour by cancer associated fibroblasts.||Drew P & Smith E||Faculty of Health Sciences divisional scholarship, University of Adelaide|
|Kean Kuan||MResearch, The University of Adelaide||2016||Factors influencing transplant surgery: ex vivo porcine pancreas normothermic perfusion||Maddern G, Trochsler M & Chung W|
Surgery is the best chance to cure cancers in the liver. During surgery blood vessels may be clamped to control bleeding. This can lead to ischemia-reperfusion (IR) injury, which increases complications and mortality. There is no effective treatment.
In Australia there has been a recent alarming increase in men of oesophageal cancer. About 50% of patients are unsuitable for surgery at the time of diagnosis, and the five year survival is less than 15%.
Prostate cancer is the most commonly diagnosed cancer in Australia and the 4th leading cause of mortality amongst Australian males. Oesophageal adenocarcinoma is the most rapidly increasing cancer in Australia and has a male: female ratio of around 8:1.
This initiative sets out to bring together a group of experienced and practising clinicians together with an experienced translational researcher all working within the Central Adelaide Health region including the Royal Adelaide and The Queen Elizabeth Hospitals to direct research scientists working within the scope of colorectal primary and metastatic disease.
Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world, accounting for over 9% of all cancer incidences. The majority of CRC related deaths are attributable to liver metastasis (LM) – the most critical prognostic factor observed in ≈50% of CRC patients.
An estimated 9 million abdominal surgeries occur each year, with up to a staggering 95% of these resulting in the formation of intra-abdominal adhesions. The presence of adhesions may go unnoticed until clinical manifestations arise such as pain, reduced gastrointestinal function or bowel obstruction leading to the need for repeat surgical intervention.
|Chief Investigators||Granting body||Project Title||Type of Grant||Total Grant Amount||Funding Period|
|BEAT Cancer||Individualised risk assessment and therapeutic interventional for colorectal cancer in the South Australian|
|Hospital Research Package||$1,500,000||2014 - 2019|
|Maddern GJ, Roberts M, Crawford D||NHMRC||Advanced imaging to define hepatic and intestinal drug disposition in aging and liver disease||Project Grant||$735,820||2013 - 2015|
|Maddern GJ, Runciman W, Mandel C, Schultz T, Munn Z||HCF Health and Medical Research Foundation||Use of surgical and radiology checklists in Australian hospitals: uptake, barriers and enablers||$311,195||2013 - 2015|
|Maddern GJ, Wormald PJ, S Moratti S, Robinson B, Robinson S||NHMRC||In vivo evaluation of the safety and efficacy of a novel chitosan gel in the reduction of adhesions following abdominal surgery in both animal and human models||Project Grant||$514,975||2013 - 2015|
|Rogers WA, Johnson AJ, Townley C, Sheridan J, Ballantyune A, Lotz M, Meyerson D, Tomosey GF, Eyers AA, Maddern GJ, Thomson CJ||ARC||On the cutting edge: promoting|
best practice in surgical innovation
|Linkage Grant||$255,000||2011 - 2014|
|Maddern GJ, Fitridge R, Boult M, Golledge J, Thompson M, Barnes M||NHMRC||Prospective evaluation of a model to predict outcomes following endovascular aortic aneurysm repair||Project Grant||$1,036,925||2009 - 2013|
|Maddern GJ, Wormald PJ, Jamieson G, Fitridge R, Hewett P||The Hospital Research Foundation (THRF)||Development and assessment of novel surgical technologies and their introduction into the Australian healthcare system||Program Grant||$1,250,000||2009 - 2013|
|Professor Ashley Dennison, MBChB, MD, FRCS||Consultant Hepatobiliary and Pancreatic Surgeon||University Hospitals of Leicester||Leicester||United Kingdom|
|Professor Richard Stubbs, MD, FRCS, FRACS||Consultant Surgeon & Director||The Wakefield Clinic||Wellington||New Zealand|
|Professor Jun Feng Liu||Head, Department of Thoracic Surgery||Fourth Hospital, Hebei Medical University||Shijiazhuang||China|
|Associate Professor Timothy Underwood||Consultant Upper GI surgeon||University of Southampton & University Hospital Southampton||Southampton||United Kingdom|