• About
  • People
  • Projects
  • Key Publications
  • Funding
  • Collaborations

The Translational Vascular Function Research Collaborative undertakes basic, clinical and epidemiological studies into cardiovascular disorders with the objective of improving the health of these patients. Currently the group focuses upon coronary heart disease and peripheral artery disease, although many principles are applicable to other vascular disorders. We aim to conduct interdisciplinary research using a collaborative approach – with results being directly integrated into clinical practice where possible. The research group includes both physicians and medical scientists located at the Basil Hetzel Institute, The University of Adelaide Medical School and The Queen Elizabeth Hospital. The integrative nature of the group provides a unique opportunity to ensure that innovations are translated from bench to bedside to health outcome, as well as the reverse.

We welcome new students to join our group where they can be involved in a diverse range of projects with diverse opportunities. We offer exceptional supervising and mentoring, and provide opportunities for students to participate in vacation research electives, Honours or PhD programs. Our projects, available through the University of Adelaide, include:

  • innovative research studies harnessing knowledge from basic science to those identify new approaches to prevent, diagnose and treat cardiovascular disease, particularly in the emerging field of coronary microvascular dysfunction.
  • a strong focus on cardiovascular health care and patient outcomes with projects to ensure new treatments and research knowledge assist the patient and are implemented correctly.
  • the opportunity to improve health care quality by helping clinicians in their health-care decision making and strengthening the patient-clinician relationship.

Researchers

Additional Research Staff Members

NamePositionEmail address
Carly CilentoCADOSA Research Officercarly.cilento@adelaide.edu.au
Michael ContibasCADOSA Research Officermichael.contibas@adelaide.edu.au
Bang HoangCADOSA Research Officerbang.hoang@adelaide.edu.au
Dr Amenah JaghooriCALHN Scientific Officeramenah.jaghoori@adelaide.edu.au
Rachel JakobczakCALHN Scientific Officerrachel.jakobczak@adelaide.edu.au
Meredith MatthewsCADOSA Research Officermeredith.matthews@sa.gov.au
Ellen ReesCADOSA Research Officerellen.rees@sa.gov.au
Laura SimeoneCADOSA Research Officerlaura.simeone@sa.gov.au
Corrado TavellaCADOSA Research Officercorrado.tavella@adelaide.edu.au

Student Alumni (since 2016)

NameDegreeYear AwardedThesis titleSupervisorsScholarship
Victor LaminPhD, The University of Adelaide2017Molecular mechanisms of sex-differences in vascular reactivity of human internal mammary arteryProf John Beltrame & Dr David WilsonInternational Postgraduate Research Scholarships (IPRS, tuition fees) and an Australian Postgraduate Award (APA)
Tharshy PasupathyPhD, The University of Adelaide2016Novel clinical insights into myocardial infarctionProf John Beltrame & Dr Rosanna TavellaAustralian Postgraduate Award (APA)
Professor John Beltrame: Student Research Projects for 2020
Project 1 Title: Coronary Angiogram Database of South Australia (CADOSA): Improving health outcomes in patients undergoing coronary angiography Description:Coronary angiography is the clinical benchmark technique in the assessment of coronary artery disease with more than 6,000 performed in South Australia each year. Despite its diagnostic benefits in identifying the presence of coronary disease, its benefit to the patient has been less rigorously studied and will be the focus of this project. CADOSA is an internationally renowned clinical registry incorporating global links with organizations including the American College of Cardiology National Cardiovascular Data Registry and the International Consortium of Health Outcomes Measurement (ICHOM). Projects Available: Honours and HDR Location: Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital Special Requirements: DCSI Clearance, Vaccinations  The research project is available for semester 1 start though mid-year entry may be considered.   Project 2 Title: Clinical and Vasomotor Studies of Patients with Myocardial Infarction and Non-Obstructive Coronary Arteries (MINOCA) Description: Approximately 5-10% of patients who experience a myocardial infarct do not have significant coronary artery disease, prompting the clinical question of what is the underlying mechanism? This project will (i) integrate with established registry studies to assess clinical outcomes and health status of MINOCA patients and (2) utilise invasive and non-invasive clinical techniques to elucidate potential mechanisms that may be responsible for the myocardial infarct. Projects Available: Honours and HDR Location: Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital Special Requirements: DCSI Clearance, Vaccinations The research project is available for semester 1 start though mid-year entry may be considered.
Molecular Physiology Projects

This group focuses on the pathophysiology and molecular signaling of vascular disorders. Laboratory studies include the assessment of isolated human vessel function using myography, followed by a series of biomolecular assays aimed to provide a mechanistic understanding of the disorders and thus direct the translation to improvements in medical therapy.

Clinical Physiology Projects

This clinical research team utilises both invasive and/or non-invasive techniques to identify the presence of vascular dysfunction in patients with vascular symptoms including angina and intermittent claudication. These include the assessment of coronary artery spasm, coronary blood flow, cardiac magnetic resonance imaging, popliteal artery vasodilation, subcutaneous blood flow and endothelial function.

South Australian Cardiovascular Outcomes Registry (SACOR)

This group focuses upon the health status of patients with vascular disorders including their symptomatic status, associated physical limitations and quality of life.

also refer to p100 of BHI Research Report 2017
International standardization of diagnostic criteria for vasospastic angina

Beltrame JF, Crea F, Kaski JC, Ogawa H, Ong P, Sechtem U, Shimokawa H, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS). International standardization of diagnostic criteria for vasospastic angina. Eur Heart J; 2015. Aug 4. pii: ehv351. [Epub ahead of print]

Standardized Outcome Measurement for Patients With Coronary Artery Disease: Consensus From the International Consortium for Health Outcomes Measurement (ICHOM)

McNamara RL, Spatz ES, Kelley TA, Stowell CJ, Beltrame J, Heidenreich P, Tresserras R, Jernberg T, Chua T, Morgan L, Panigrahi B, Rosas Ruiz A, Rumsfeld JS, Sadwin L, Schoeberl M, Shahian D, Weston C, Yeh R, Lewin . Standardized Outcome Measurement for Patients With Coronary Artery Disease: Consensus From the International Consortium for Health Outcomes Measurement (ICHOM). J Am Heart Assoc; 2015. 4(5): e001767.

Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries

Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation; 2015. 131(10):861-70.

The prevalence of weekly angina among patients with chronic stable angina in primary care practices: The Coronary Artery Disease in General Practice (CADENCE) Study

Beltrame JF, Weekes AJ, Morgan C, Tavella R, Spertus JA. The prevalence of weekly angina among patients with chronic stable angina in primary care practices: The Coronary Artery Disease in General Practice (CADENCE) Study. Arch Intern Med; 2009.169(16): 1491-9.

The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon

Beltrame JF, Turner SP, Leslie SL, Solomon P, Freedman SB, Horowitz JD. The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon. J Am Coll Cardiol; 2004. 44(1): 57-62.

Funding since 2010

Chief InvestigatorsGranting bodyProject TitleType of GrantTotal Grant AmountFunding Period
Beltrame JF, Tavella R, Zeitz C, Spertus J, Arstall M, Worthley M, Chew DNHMRC (#1062331)Value-Based Healthcare in Elective Coronary StentingPartnership Grant$2,440,2232018 - 2021
Zalewski P, Hodge S, Beltrame J, Murgia C, Tavella RNHMRC (#1138917)Role for Zinc and ZIP2 in the action of nitric oxide and in vascular protection against cigarette smoke and cardiovascular diseaseProject Grant$685,9412018 - 2020
Appleton S, Adams R, Beltrame JThe Hospital Research FoundationBroken Sleep - Broken Heart? Longitudinal follow-up of cardiovascular and cognitive outcomes in middle aged and older men in North-West-AdelaideProject Grant$147,0002018 - 2019
Dreyer RNHMRC (#1111039)
Sex Differences in Long-Term Outcomes of
Young Patients with Acute Myocardial Infarction
Sidney Sax
Public Health Early
Career Fellowship
(Overseas)
$111,300 pa2016 - 2019
Beltrame J, Zeitz C, Lindahl BThe Hospital Research Foundation (THRF)Potential mechanisms and treatment of post-infarct angina in patients with Myocardial Infarction with Non Obstructive Coronary Arteries (MINOCA)Basil Hetzel Translational Grant$750,0002017 - 2018
Beltrame JFThe University of AdelaideThe anti-anginal benefits of Zibotentan in the Coronary Slow Flow Phenomenon (CSFP)Commercial Accelerator Scheme (CAS) Project$87,0002017 - 2018
Hodge S, Zalewski P, Roscioli ENHMRC (#1099040)
Exploiting increased autophagy in
bronchial epithelial cells: a new therapeutic
approach for chronic obstructive
pulmonary disease (COPD)
Project Grant$745,3902016 - 2018
Adams R, Appleton SL, McEvoy RD, Beltrame JHeart FoundationCardiovascular impacts of obstructive sleep apnea in menVanguard$75,0002017
Tavella R, Beltrame JF, Zeitz C, Ranasinghe IHeart FoundationEVALuation of Appropriate UsE of Elective Percutaneous Coronary Intervention - Value of PCIVanguard$75,0002017
Tavella RHeart Foundation (Tom Simpson Trust Fund)Coronary Angiogram Database of South Australia (CADOSA) BiobankEquipment Grant$14,0302017
Zalewski P, Hodge S, Beltrame J, Murgia C, Tavella RThe University of AdelaideEndothelia zinc deficiency as a previously unrecognized factor linked to cardiovascular disease risk factorsInvestment for Success NHMRC near-miss grant$9,9922017
Beltrame JF, Zeitz CJ, Worthley MI, Arstall MA, Tavella RAstra Zeneca: ESR-14-10465Ticagrelor In Coronary microvascular dysfunction (TIC) Program: Anti-anginal effficacy in primary coronary microvascular disordersProject Grant$300,0002016 - 2017
Ranasinghe I, Beltrame J, Tavella R, Zeitz C, Mazumdar S, Cooper BHCF Research Foundation: IRUA2015149Reducing unwarranted variation in early complications after cardiac pacemaker and defibrillator implantation among Australian hospitalsProject Grant$250,0002016 - 2017
Beltrame JF, Zeitz CJ, Tavella R, Worthley MINHMRC (#1062331)The ACCESS Project -Assessment of Coronary artery disease using Ct Effectively for Stable SymptomsPartnership Grant$1,564,1652013 - 2017
Beltrame JF, Elliott A, Rajopadhyaya K, Fitridge RThe Hospital Research Foundation (THRF)Exercise Therapy for the Management of the Coronary Slow Flow Phenomenon$300,0002014 - 2015
Beltrame J, Worthley S, Chew DSouth Australian Cardiovascular Research DevelopmentChronic Refractory Angina - Defining its Characteristics and Exploring Endothelin Blockade as a New Potential TherapyProgram Grant$1,327,6522011 - 2014
Horowitz J, Beltrame J, Morris R, Fitridge R, Zeitz C, Wilson DP, Sallustio B, Chirkov Y, Kennedy J, Cowled PThe Hospital Research Foundation (THRF)TQEH Vascular Disease and Therapeutics Research Group: towards improved outcomes for vascular diseasesProgram Grant$1,040,0002009 - 2014
Tavella RNational Heart Foundation Tom Simpson Trust FundThe Coronary Angiogram Database of South Australia (CADOSA) BiobankEquipment Grant$12,5002014
Beltrame JF, Zeitz CJ, Worthley MI, Arstall MA, Tavella RAstra Zeneca: ESR-14-10465Ticagrelor In Coronary microvascular dysfunction (TIC) Program$368,6412014
Beltrame JF, Zeitz CJ, Worthley MI, Arstall MAUniversity of Adelaide, Discipline of MedicineThe Coronary Angiogram Database of South Australia (CADOSA) BiobankEquipment Grant$10,0002013

CollaboratorPositionInstitutionCityCountry
Michael Worthington, James Edwards, Fabiano Viana, Robert StuklisCardio Thoracic Surgical Unit (CTSU)Royal Adelaide HospitalAdelaideAustralia
Professor Andrew Tonkin Head of Cardiovascular Research UnitDepartment of Epidemiology and Preventive Medicine,
Monash University
MelbourneAustralia
Dr Andrew Weekes

Medical Affairs Manager Servier Laboratories Australia
Professor Christopher Reid Associate DirectorMonash Centre of Cardiovascular Research and Education in TherapeuticsMelbourne Australia
Professor C. Noel Bairey MerzMedical DirectorCedars-Sinai Medical CentreLos AngelesUSA
Professor John Spertus Professor of Medicine
& Director of Education and Cardiovascular Outcomes Research
University of Missouri, Kansas City & Mid America Heart Institute, St Luke’s HospitalKansasUSA
Professor Peter Ganz
Maurice Eliaser Jr Distinguished Professor of Cardiovascular Medicine
& Chief, Division of Cardiology
San Francisco School of Medicine, University of California
& San Francisco General Hospital
San FranciscoUSA
Professor Harlan Krumholz Harold H. Hines, Jr Professor of Medicine & Epidemiology & Public Health (Cardiology) Department of Internal Medicine, School of Medicine, Yale UniversityNew HavenUSA
Professor Attilio Maseri PresidentItalian Heart Care Foundation FlorenceItaly
Professor Hiroaki Shimokawa
Professor and Chairman, Department of Cardiovascular Medicine Graduate School of Medicine, Tohoku University SendaiJapan
Dr Guy Eslick Research FellowDepartment of Epidemiology, Harvard School of Public HealthBostonUSA
Dr Caleb Stowell Vice President of Standardization and Business Development International Consortium for Health Outcomes Measurement (ICHOM), Harvard Business School, Boston Consulting Group & the Karolinska InstituteBoston & StockholmUSA & Sweden
Dr Neil Oldridge Senior Scientist &
Director, Fellowship Training
College of Health Sciences, University of Wisconsin-Milwaukee & Heart Care Associates MilwaukeeUSA