• About
  • People
  • Projects
  • Clinical Trials
  • Key Publications
  • Funding
  • Collaborations

The research focus of the Respiratory Medicine and Clinical Practice Unit (CPU) is to conduct evidence based medicine evaluations with the primary aim of research translation. With an emphasis on best-practice clinical care for COPD, asthma, bronchiectasis, pneumothorax, sleep apnoea, tobacco-related illnesses and Indigenous respiratory health, the research being done by these units directly impact the clinical care received by patients attending public hospitals in South Australia and Internationally. The unit increasingly looks to innovative approaches (e.g. using new technologies, smartphone apps and the internet) to improve our patients lives. The CPU has been based at the BHI since the building first opened its doors in 2009.

Honours and Postgraduate Student Supervision

Building a quality research track record is an essential component for any early career researcher, and this award-winning multi-disciplinary unit facilitates these opportunities. The unit offers potential Honours, Masters and PhD student’s support but also flexibility to pursue areas of interest within the scope of evidence based medicine, epidemiology and respiratory health. We currently have over 50 projects underway for health priority areas including Indigenous health, COPD, asthma and tobacco using novel medical procedures and devices and innovative use of electronic resources including apps such as augmented reality. Research can take on a number of forms including hospital based randomised placebo controlled trials, retrospective evaluations and qualitative research, all with the potential to make practical real-world impact, attract high impact publications, conference presentations, media attention, grants, fellowships and prestigious awards.

Researchers

Additional Research Staff Members

NamePositionEmail address
Anil RoyClinicianAnil.Roy@sa.gov.au
Antony VealeClinicianAntony.Veale@sa.gov.au
Jonathon PolasekClinicianJonathon.Polasek@sa.gov.au
Binh TruongClinical Trials and Project Researcherbinh.truong@sa.gov.au
Anne TabnerClinical Trialsanne.tabner@sa.gov.au
Donna KeatleyPulmonary Function Test (PFT) Laboratory SupervisorDonna.Keatley@sa.gov.au
Pamela KiddPFT Laboratory Scientistpamela.kidd@sa.gov.au
Xiao Hui LiuPFT Laboratory TechnicianXiaoHui.Liu@sa.gov.au
Vanessa CoeSleep Laboratory TechnicianVanessa.Coe@sa.gov.au
Nathan ElgarSleep Laboratory TechnicianNathan.Elgar@sa.gov.au

Student Alumni (since 2016)

NameDegreeYear AwardedThesis titleSupervisorsScholarship
Zafar UsmaniPhD, The University of Adelaide2018Treatment of anxiety among patients with Chronic Obstructive Pulmonary DiseaseSmith B, Esterman AJ
Charmaine KingHonours, The University of Adelaide2016The use of innovative technology to deliver health interventions for asthmaCarson K, Smith B and van Agteren JThe Hospital Research Foundation honours scholarship
Kristin CarsonPhD, The University of Adelaide2015, with Dean's commendation for doctoral thesis excellenceAdvancing treatment options for tobacco cessation, prevention and related illnesses, with particular reference to Indigenous populationsSmith B, Esterman A, Veale A and Peters MJ

 

In-hospital clinical trials
  • POC-study: Randomized Crossover Trial of portable oxygen cylinders versus battery powered portable oxygen concentrators
  • PAC-study: Paroxetine for Anxiety in Patients with Chronic Obstructive Pulmonary Disease.
  • STOP-project: The Smoking Termination Opportunity for inPatients project
  • NRT-study: Nicotine receptor up-regulation with transdermal nicotine patches
Models of Care
  • e-ACCORD: Advancing inpatient management of COPD through redesign & implementation of evidence-based guidelines for the management of COPD
  • South Australian Ambulance Service (SAAS) and Central Adelaide Local Health Network (CALHN), Chronic Obstructive Pulmonary Disease (COPD) at Home Service: Reducing avoidable hospital presentations
  • Efficacy of a Single-night Multiple-split Diagnostic and Therapy Assessment for Type II Respiratory Failure using Positive Airway Pressure and Supplemental Oxygen.
Smoking & Healthy Living
  • Indigenous tobacco cessation in adults and prevention amongst youth
  • Community and mass media interventions to prevent smoking in youth
  • Kick.it: the development of a social network-based smoking cessation platform for mobile devices.
  • Depression in Indigenous Populations
Cochrane reviews
  • Nurse-led care for the management of bronchiectasis
  • Aspiration v tube drainage for spontaneous pneumothorax
  • Home care outreach nursing in COPD
  • Gastro-oesophageal reflux treatment for asthma
  • Interventions for smoking cessation in Indigenous populations
  • Interventions for tobacco prevention in Indigenous youth
  • Psychological interventions for anxiety in COPD
  • Psychological interventions for depression in COPD
  • Pharmacological interventions for depression in COPD
  • Pharmacological interventions for anxiety in COPD
  • Prolonged antibiotics for bronchiectasis
  • Anticoagulants for idiopathic pulmonary fibrosis
  • Physical training for asthma
  • Lung Volume Reduction Surgery in Diffuse Emphysema
  • Minimally Invasive Techniques for Lung Volume Reduction in Severe Emphysema
  • Asthma-self management education with either regular healthcare professional review or written action plan or both for adults
  • Ambulatory oxygen for people with COPD who are not hypoxemic at rest
  • Community interventions for preventing smoking in young people
  • Mass media interventions for preventing smoking in young people
  • Training health professionals in smoking cessation
  • Community pharmacy personnel interventions for smoking cessation
  • Consumer guidelines for chronic disease management
  • Continuous positive airway pressure for obstructive sleep apnoea in adults
  • Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbation of asthma
  • Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of COPD
  • Nurse specialists care for bronchiectasis
  • Oxygen therapy in the pre-hospital setting for acute exacerbations of COPD
  • Prolonged antibiotics for non-cystic fibrosis bronchiectasis in children and adults

Please Professor Brian Smith on 8222 6670 if you are interested in participating in either of the following In-hospital Clinical Trials:

  • POC-study: Randomized Crossover Trial of portable oxygen cylinders versus battery powered portable oxygen concentrators
  • PAC-study: Paroxetine for Anxiety in Patients with Chronic Obstructive Pulmonary Disease
Smoking Termination Opportunity for inPatients (STOP): Superiority of a course of varenicline tartrate plus counselling over counselling alone for smoking cessation: A 12-month randomised controlled trial for inpatients

Smith BJ, Carson KV, Brinn MP, Labiszewski NA, Peters M, Fitridge R, Koblar S, Jannes J, Veale A, Goldsworthy S, Litt J, Edwards D, Esterman AJ. Smoking Termination Opportunity for inPatients (STOP): Superiority of a course of varenicline tartrate plus counselling over counselling alone for smoking cessation: A 12-month randomised controlled trial for inpatients. Thorax 2013; 68(5): 485-6 

Smith BJ, Carson KV, Brinn MP, Labiszewski NA, Peters M, Fitridge R, Koblar S, Jannes J, Veale A, Goldsworthy S, Litt J, Edwards D, Esterman AJ. Smoking Termination Opportunity for inPatients (STOP): Superiority of a course of varenicline tartrate plus counselling over counselling alone for smoking cessation: A 12-month randomised controlled trial for inpatients. ;

Psychological therapies for the treatment of anxiety disorders in chronic obstructive pulmonary disease

Usmani ZA, Carson KV, Heslop K, Esterman AJ, De Soyza A, Smith BJ. Psychological therapies for the treatment of anxiety disorders in chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2013, Issue 8

Usmani ZA, Carson KV, Heslop K, Esterman AJ, De Soyza A, Smith BJ. Psychological therapies for the treatment of anxiety disorders in chronic obstructive pulmonary disease. ;

Interventions for smoking cessation in Indigenous populations

Carson KV, Brinn MP, Peters M, Veale A, Esterman AJ, Smith BJ. Interventions for smoking cessation in Indigenous populations. Cochrane Database of Systematic Reviews 2012, Issue 1.

Carson KV, Brinn MP, Peters M, Veale A, Esterman AJ, Smith BJ. Interventions for smoking cessation in Indigenous populations. ;

Safety of a course of varenicline tartrate and counselling over counselling alone for smoking cessation: A 52 week randomised controlled trial for inpatients (STOP Study)

Carson KV, Smith BJ, Brinn MP, Peters M, Fitridge R, Koblar S, Jannes J, Veale A, Singh K, Goldsworthy S, Litt J, Edwards D, Esterman AJ. Safety of a course of varenicline tartrate and counselling over counselling alone for smoking cessation: A 52 week randomised controlled trial for inpatients (STOP Study). Nicotine and Tobacco Research 2014

Carson KV, Smith BJ, Brinn MP, Peters M, Fitridge R, Koblar S, Jannes J, Veale A, Singh K, Goldsworthy S, Litt J, Edwards D, Esterman AJ. Safety of a course of varenicline tartrate and counselling over counselling alone for smoking cessation: A 52 week randomised controlled trial for inpatients (STOP Study). ;

The COPD X Plan: Australian and New Zealand Guidelines for the management of chronic obstructive pulmonary disease

Smith B with other contributors on behalf of TSANZ. The COPD X Plan: Australian and New Zealand Guidelines for the management of chronic obstructive pulmonary disease; 2014; 16(11): 1495-1502

Smith B with other contributors on behalf of TSANZ. The COPD X Plan: Australian and New Zealand Guidelines for the management of chronic obstructive pulmonary disease. ;

Funding since 2010

Chief InvestigatorsGranting BodyProject TitleType of GrantTotal Grant AmountFunding Period
Smith B, Carson KV, Esterman A,
Peters M, Gould G
NHMRC (#1108309)
Training health professionals in tobacco
cessation and evidence translation for
Aboriginal Australians
Project grant$185,725 pa2016-2018
Carson KVNHMRC (#1092680)
and Cancer
Australia (cofunded)
Translating Research into Practice
Fellowship
TRIP Fellowship$136,456 pa2015-2016
Van Agteren JEM, Smith BJThe Hospital Research Foundation (THRF)Kick.it: the development of a social network-based smoking cessation platform for mobile devices.THRF 50th Anniversary Awards$25,0002015
Carson KV, Smith BJNHMRCTraining Health Professionals in smoking cessation and tobacco abuse prevention for Aboriginal AustraliansTRIP Fellowship (Translating Research In to Practice)$172,9112014 - 2017
Carson KV, Smith BJCancer AustraliaTraining Health Professionals in smoking cessation and tobacco abuse prevention for Aboriginal AustraliansCo-funding for NHMRC TRIP Fellowship$100,0002014 - 2017
Carson KV, Smith BJThoracic Society of Australia and New Zealand (TSANZ)Training Health Professionals in smoking cessation and tobacco abuse prevention for Aboriginal AustraliansTSANZ Robert Pierce Grant-in-Aid$15,0002015 - 2016
Walters J, Walters H, Holland A, Yang I, Gibson P, Smith BJNHMRCAustralasian Satellite of the Cochrane Airways Group Centre for Research Excellence$69,0002013 - 2016
Carson KV, Peters M, Esterman AJ, Veale A, Smith BJAustralian and New Zealand School of GovernmentInterventions for smoking cessation and prevention in Indigenous populations $10,0002013-2015
Clifton V (Smith BJ Associate Investigator)NHMRCEffect of asthma during pregnancy on placenta and foetus $216,5502009 - 2011
Robertson M, Smith BJ, Robertson T, Carson K, Ward M The Hospital Research Foundation (THRF)Nicotine receptor up-regulation evaluation $20,0002010-2012

Projects with Local Collaborators

Project TitleInstitutions involved
Home care outreach nursing for COPDThe University of Adelaide, The University of South Australia, The Royal Adelaide Hospital
Anticoagulants for idiopathic pulmonary fibrosisThe University of Adelaide, The University of South Australia, The Royal Adelaide Hospital
Mandibular advancement for Obstructive Sleep ApnoeaRepatriation General Hospital, Flinders Medical Centre, The University of Adelaide, The University of South Australia

Projects that include Local and National Collaborators

Project TitleInstitutions involved
Electronic best practice guidelines for the management of COPDSA Health, The University of Adelaide, The University of South Australia
NRT studyTherapeutics Research Group TQEH, Department of Medicine, The University of Adelaide, Hanson Institute, The University of Queensland
ACAGN (Australian Cochrane Airways Group Network)University of Tasmania, University of Newcastle, Menzies Institute, The University of Queensland, La Trobe University, Monash University
Indigenous Respiratory healthThe Thoracic Society of Australia and New Zealand, Concord Hospital, The University of Sydney, The University of Western Australia, The University of Adelaide, The University of South Australia, James Cook University, Menzies School of Health Research, Aboriginal Health Council of South Australia, Murray Mallee Community Health Service, Cancer Australia, Smokers Clinic Brain Mind and Research Institute, Australian and New Zealand School of Government, NSW Health (North Coast Area Health Service); Community participants from Adelaide and Murray Bridge
Asthma self-management educationRepatriation General Hospital, University of Tasmania, The University of Adelaide, The University of South Australia, Joanna Briggs Institute, Flinders University
Lung volume reduction surgery for diffuse emphysemaJohn Hunter Hospital, The University of Newcastle, Repatriation General Hospital, The University of Adelaide, The University of South Australia
Consumer guidelines for chronic disease managementThe University of Adelaide, The University of South Australia, Concord Hospital, The University of Sydney, University of Tasmania
Gastro-oesophageal reflux treatment for asthma in adults and childrenFlinders Medical Centre, The University of Adelaide, Alice Springs Hospital

Projects that include Local, National & International Collaborators

Project TitleInstitutions involved
Indigenous tobacco cessation in adults and prevention amongst youthJames Cook University, The University of Adelaide, The University of South Australia, Menzies School of Health Research, Aboriginal Health Council of South Australia, Community participants from Adelaide and Murray Bridge, University of Ottawa Heart Institute, Canada
Community and mass media interventions to prevent smoking in youthTehran University, Iran, Menzies Institute, University of Adelaide, The University of South Australia, University of Ottawa Heart Institute, Canada
Community pharmacy interventions for smoking cessationThe University of Aberdeen, UK, The University of South Australia, The University of Adelaide, Oxford University, UK
CPAP for obstructive sleep apnoeaSt George’s Hospital, UK, The Cochrane Collaboration, UK, York District Hospital, UK, Bradford Royal Infirmary, UK, The University of Adelaide, The University of South Australia
Non-invasive ventilation for COPD and asthmaMonash University, Austin Hospital (Victoria, Australia), University of Southampton, UK, St James University Hospital, Leeds, UK, Royal Free and University College Medical School, London, UK, Katholieke Universiteit Leuven, Leuven, Belgium
Pharmacological interventions for the treatment of depression in COPDThe University of Adelaide, The University of South Australia, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK, Newcastle University, Newcastle, UK
Nurse specialist care for bronchiectasisUniversity of Sheffield, Sheffield, UK, The University of Adelaide, The University of South Australia
Prolonged antibiotics for purulent bronchiectasisHemel Hempstead Hospital, Hemel Hempstead, UK, Castle Hill Hospital, Cottingham, UK, Flinders Medical Centre, The University of Adelaide, The University of South Australia
Psychological interventions for the treatment of anxiety in COPDNewcastle upon Tyne NHS Hospitals Foundation Trust, Newcastle upon Tyne, UK, Newcastle University, Newcastle, UK, The University of Adelaide, The University of South Australia
Psychological interventions for the treatment of depression in COPDThe University of Adelaide, The University of South Australia, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK, Newcastle University, Newcastle, UK
Simple aspiration versus intercostal tube drainage in primary pneumothoraxRoyal College of Surgeons in Ireland, Dublin, Ireland, Our Lady’s Children’s Hospital Crumlin, Dublin, Ireland, Cork University Hospital, Cork, Ireland, The University of Adelaide, The University of South Australia
Training health professionals in smoking cessationLeiden University Medical Centre, Leiden, Netherlands, Radbound University Nijmegen Medical Centre, Nijmegen, Netherlands, The University of Adelaide, The University of South Australia
STOP studyRoyal Adelaide Hospital, Lyell McEwin Hospital, The University of Adelaide, The University of South Australia, The Cancer Council of South Australia, Flinders University, University of Sydney, University of Melbourne, Concord Repatriation General Hospital, The University of Melbourne, University of Ottawa Heart Institute, Canada