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Our research focusses on the role of the microbiome and diet in inflammatory bowel disease (IBD) and other gut disorders and manipulating the microbiome and diet for therapeutic effect.

We have demonstrated that faecal microbiota transplantation can safely induce remission of active ulcerative colitis but that the clinical effect diminishes with time. This provides evidence that this new therapy is both effective and practical in terms of delivery for patients. It is a therapeutic option for patients that does not result in immune suppression that many current therapies do. We have also established a not for profit organisation “BiomeBank” with The Hospital Research Foundation (THRF) that will run the stool bank that is also used to treat South Australian patients with recurrent Clostridium difficile infection.

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Chief InvestigatorsGranting bodyProject TitleType of GrantTotal Grant AmountFunding Period
Costello S, Bryant RThe Hospital Research Foundation (THRF)BiomeBank establishmentEstablishment Grant$100,0002018 - 2019
Costello S, Bryant RThe Hospital Research Foundation (THRF)Anaerobic ChamberEquipment Grant$41,4752017
Bryant RGastroenterology Society of AustraliaEstablishing an IBD gastrointestinal ultrasound service in South AustraliaGESA Ferring IBD Clinician Establishment Award$60,0002016
Andrews J, Hughes P, Conlon M, Roberts-Thompson I, Costello SNHMRCFaecal microbiota transplant for ulcerative colitis: A randomised controlled trialProject Grant$695,8952015 - 2017

Industry collaboration with Microbiotica announced on 21 June 2018.

CollaboratorInstitutionCityCountry
Professor Jane AndrewsRoyal Adelaide HospitalAdelaideAustralia
Dr Michael ConlonCSIROAdelaideAustralia
Dr Patrick HughesThe University of AdelaideAdelaideAustralia
Dr Lito PapanicolasFlinders Medical CentreAdelaideAustralia
Dr Oliver WatersFiona Stanley HospitalFremantleAustralia
Dr Trevor LawleySanger InstituteCambridgeUK
Professor Simon TravisUniversity of OxfordOxfordUK