Speaker: Associate Professor Claudine Bonder, Head, Vascular Biology and Cell Trafficking Laboratory Centre for Cancer Biology University of South Australia & SA Pathology
Title: Desmoglein-2 in endothelial cells: getting to the heart of the matter
Chair: Dr Peter Zalewski, Senior Research Officer, University of Adelaide, Discipline of Medicine. Located Level 2 BHI, TQEH.
Speaker biography: A/Prof Claudine Bonder is an expert in vascular biology having trained in Australia and overseas. She currently heads the Vascular Biology and Cell Trafficking Laboratory at the Centre for Cancer Biology in Adelaide, South Australia. Her research interests focus on understanding the vasculature and cell trafficking during normal and disease states and her laboratory has a number of areas of interest. Firstly, vasculogenic mimicry (VM), a process wherein cancer cells themselves form vascular-like structures to increase access to the blood supply to assist in tumour growth. The VBCT laboratory has begun to identify novel elements in VM and are now targeting these in an attempt to prevent the progression of breast cancer and melanoma. Secondly, endothelial progenitor cells (EPCs) directly contribute to blood vessel formation (vasculogenesis) and can be used to support organ transplantation. The VBCT laboratory is developing smart surface biomaterials to co-transplant EPCs with insulin-producing beta islet cells for increased cure rate of patients with type 1 diabetes.
A/Prof Bonder has published ~60 research publications (including Immunity, Journal of Clinical Investigation, American Journal of Pathology and Blood) in addition to invited reviews and book chapters. She has received distinguished accolades from her peers including an Early Career Research Award from the Australian Academy of Science in 2005, a Young Tall Poppy award in 2009 and was an ASMR Leading Light finalist in 2013. She has been awarded Category 1 funding from the NHMRC, Heart Foundation, CRC for Biomarker Translation, Cell Therapy Manufacturing CRC and Cancer Council SA and filed four patents in vascular biology.