Speaker: Associate Professor Ivan Kempson, Foundation Fellow, Future Industries Institute, University of South Australia
Title: Cell sub-population responses to nanoparticle radioesensitisation
Chair: Dr Amy Holmes, Postdoctoral Researcher, Therapeutics Research Centre, University of South Australia. Level 2 BHI, TQEH. [email protected]
Speaker Biography: Ivan Kempson is a Foundation Fellow and Associate Professor in Biophysics at the Future Industries Institute, University of South Australia. After completion of his PhD he was awarded an Australian Synchrotron Research Program Fellowship funded by ANSTO on trace material characterisation that lead to a position in the Institute of Physics, Academia Sinica, Taiwan, before he returned to Australia in 2013. He also represents Australia at the International Atomic Energy Agency on a variety of Technical Meetings and a Collaborative Research Program.
His research is based on novel analytics for understanding bio-inorganic interactions in relation to protein adsorption on materials and nanoparticle fate in experimental therapeutics. This talk focuses on cross-correlative imaging for quantifying the impact of nanoparticle content with DNA breaks in individual cells after irradiation with clinical radiotherapy sources. Nanoparticles have entered several human trials, yet the mechanisms of their impact on enhancing radiobiological effects are largely unknown. The outcomes of the research presented in this seminar are assisting in understanding the fundamental mechanisms of radiosensitisation, modelling of radiotherapy planning and correlating nanoparticle parameters with radiobiological response for quality-by-design as we move toward our own human trials.