- About
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Our primary research interest is Breast Cancer and Bone Metastasis as breast cancer is the most common cancer in women that metastasises to bone. Despite recent advances, our knowledge of why bone is such a fertile “soil” for tumour cells to home in on remains poor. Our research aims to provide vigorous preclinical data that will facilitate the translation of novel therapeutics to clinical trials for bone metastases.
We have identified a novel method of treating both cancer progression and metastasis, by targeting the body’s natural immune response. Myeloperoxidase (MPO) and eosinophil peroxidase (EPO), well known for their antimicrobial activity, are released in high quantities by infiltrating immune cells in a variety of tumour types, including breast cancer. Our laboratory has shown for the first time that peroxidases are causatively involved in modulating the cancer microenvironment to promote blood vessel development and extracellular matrix biosynthesis. These processes are major hallmarks in cancer progression and as such identify peroxidases as drugable targets for cancer therapy.
Researchers
Students
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Nikolaos Filippatos
Position: Student
Group: Breast Cancer Research Unit
Theme: Cancer
Email: [email protected]
Profile: View profile
LinkedIn: Nikos Filippatos
Student Alumni (since 2016)
| Name | Degree | Year Awarded | Thesis title | Supervisors | Scholarship |
|---|---|---|---|---|---|
| Alexandra Shoubridge | PhD, University of Adelaide | 2019 | A New Role for Peroxidases in Bone Repair | Prof Andreas Evdokiou, Dr Bill Panagopoulos, Dr Mark DeNichilo and Professor Peter Anderson (WCH) | Faculty of Health Sciences Divisional Scholarship, The University of Adelaide |
| Kyle Brewer | Honours (1st class), University of Adelaide | 2017 | Injectable thermoresponsive hydrogels for adoptive cell therapies | Evdokiou A and Blencowe A (UniSA) | The Hospital Research Foundation Honours Scholarship |
| Vasilios (Bill) Liapis | PhD, University of Adelaide | 2017 | Targeting cancer in the bone with the hypoxia activated pro-drug Evofosfamide | Evdokiou A, De Nichilo M & Zinonos I | Faculty of Health Sciences Divisional Scholarship, plus Department of Surgery supplementary scholarship, University of Adelaide |
| Aneta Zysk | PhD, University of Adelaide | 2017 | Adoptive transfer of ex vivo expanded gamma delta T cells targeting osteolytic cancer in the bone | Evdokiou A and De Nichilo M | Australian Postgraduate Award |
| Vasilios (Bill) Panagopoulos | PhD, University of Adelaide | 2016 | A novel role for peroxidases in breast cancer development progression and metastasis | Evdokiou A & De Nichilo M | Faculty of Health Sciences Divisional Scholarship, plus Department of Surgery supplementary scholarship, University of Adelaide |
Funding since 2015
| Chief Investigators | Granting Body | Project Title | Type of Grant | Total Grant Amount | Funding Period |
|---|---|---|---|---|---|
| Panagopoulos V | NHMRC (#1160000) | Stromal cell-derived factor Gremlin 1 promotes tumour growth and metastasis of breast cancer | Peter Doherty Biomedical ECR Fellowship | $327,192 | 2019 - 2022 |
| Evdokiou A | Faculty of Health and Medical Sciences, The University of Adelaide | New immunotherapeutic approaches targeting incompletely resected or inoperable tumours | Leverage support for THRF project grant | $75,000 | 2018 - 2021 |
| Evdokiou A, Zinonos I | The Hospital Research Foundation | New immunotherapeutic approaches targeting incompletely resected or inoperable tumours | Project Grant | $225,000 | 2018 - 2021 |
| Sallustio B, Evdokiou A, Horowitz JD | National Health & Medical Research Council (NHMRC #1145776) | Prevention of heart damage during Anthracycline cancer chemotherapy | Project Grant | $327,214 | 2018 - 2020 |
| Sallustio BC, Evdokiou A, Horowitz JD | The Hospital Research Foundation | Vivid Iq Premium, Rodent Echocardiography System | Joint equipment funding with The University of Adelaide | $77,600 | 2018 |
| Evdokiou A, Panagopoulos V | Tour de Cure | Localised treatment of solid tumours with cytotoxic gd T cells | Project Grant | $125,000 | 2018 |
| Evdokiou A | The University of Adelaide | Localised treatment of solid tumours with cytotoxic gd T cells | Project Grant | $50,000 | 2018 |
| Townsend A, Hardingham J, Tomita Y, Yool A, Price T, Evdokiou A | The Hospital Research Foundation | Preclinical investigation of the efficacy of novel aquaporin inhibitors in preventing growth and metastasis of breast cancer | ABCR Elcombe Preclinical Project Grant | $255,000 | 2017 - 2020 |
| Panagopoulos V | The Hospital Research Foundation | Targeted inhibition of inflammatory peroxidases, a new therapeutic strategy against breast cancer and metastatic disease | Early Career Fellow | $240,000 | 2017 - 2019 |
| Evdokiou A, Zannetino A, Blencowe A | The Hospital Research Foundation | Localized treatment of solid tumours with cytotoxic gd T cells | Project Grant | $125,000 | 2017 - 2018 |
| Ingman W, Evdokiou A, Wrin J | The Hospital Research Foundation | Breaking immune tolerance in triple negative breast cancer | Project Grant | $125,000 | 2017 - 2018 |
| Evdokiou A | The Hospital Research Foundation | Michell-McGrath Breast Cancer Research Fellowship | Fellowship | $750,000 | 2016 - 2019 |
| Foreman A, Evdokiou A | Garnett Passe and Rodney Williams Foundation | Tumour-associated microbiota and its role in oral cavity cancer carcinogenesis | Conjoint | $375,000 | 2016 - 2018 |
| Evdokiou A | The Hospital Research Foundation | Uncovering a new role of peroxidase enzymes as drivers of mammographic density and breast cancer | $150,000 | 2015 - 2016 | |
| Evdokiou A | Oncolyze Inc NY, USA, | Anticancer efficacy of PNC-27 | Commercial open grant | $30,000 | 2015 - 2016 |
| Evdokiou A | University of Adelaide DVCR | $25,000 | 2015 | ||
| Evdokiou A | Adelaide Research and innovation (ARI) | Using peroxidase enzymes to accelerate fracture repair in healthy or osteoporotic bone | $85,000 | 2014 - 2015 | |
| Evdokiou A, Atkins GJ | Project Grant | $456,000 | 2013 - 2015 | ||
