Position: Principal Medical Scientist
Theme: Cardiovascular Disease
- Research Focus
Yuliy’s work interfaces basic research (“bench-side”) with extensive clinical access (“bed-side”). He has been directing projects investigating the interactions between cyclic nucleotide signalling pathways and oxidative stress in cardiovascular disease states.
Together with PhD and Honours students under his supervision, he has discovered and documented the phenomena of platelet “NO resistance” (nitric oxide, NO) and impaired cAMP signalling occurring in patients with ischaemic heart disease, and associated with thrombosis.
Yuliy’s current research focus is the clinical phenomenon of “clopidogrel resistance”. It appears that impairment in cyclic nucleotide signalling contributes to the pathophysiological mechanism of this condition.
He is available to supervise new PhD students. He also provides work experience opportunities for high school students.
Blood clots cause heart attacks and strokes. Clot formation can be prevented with special medication (e.g. clopidogrel or ticagrelor). Our research is aiming to identify a reason for the frequently occurring, less than expected response to medications designed to suppress increased blood clotting. We are focusing on platelets (little blood particles) because the starting point for blood clot formation is platelet aggregation, or platelet “clumping”. We have recently demonstrated that highly tuned regulation of platelet activity is compromised in patients with cardiovascular diseases. We are trying to work out what is going wrong with this regulation and how it could be restored. Our research will provide us with the insight into how to improve platelet regulation.
- 2001 – 2008: Senior Research Officer/Lecturer (Level B), Department of Medicine (TQEH), University of Adelaide.
- 2009 – 2014: Senior Research Fellow/Senior Lecturer (Level C), Department of Medicine (TQEH), University of Adelaide.
- 2014 – present: Principal Medical Scientist (MeS-4), The Queen Elizabeth Hospital, Central Adelaide Local Health Network (CALHN), SA Health.