- Clinical Trials
- Key Publications
The Vascular Surgery Research Group has been based at the TQEH for approximately 20 years now. Our group consists of both clinicians and laboratory researchers. Research themes address both basic laboratory science and clinical research. Major interests include peripheral arterial disease and associated impaired wound healing in patients with diabetes. Research projects address aspects of the pathophysiology of vascular inflammation and wound healing, potential therapies and their clinical implications.
Professor Robert Fitridge
Position: Lead Researcher
Phone: +61 8 8222 7711
Dr Prue Cowled
Position: Principal Medical Scientist
Phone: +61 8 8222 7541
Additional staff members
Mr Joe Dawson, Consultant Vascular Surgeon
Ms Ruth Battersby, Clinical Trials Coordinator (based at the RAH)
Alumni: Postgraduate degrees awarded since 2010
|Name||Year Awarded||Supervisors||Title of Thesis|
|PhD completions||University of Adelaide|
|Dr Nadira Ruzehaji||2013||Cowin A, Fitridge R||The role of cytoskeletal protein Flightless 1 in diabetic wound healing|
|Ms Kanchani Rhadjopadhyaya||2013||Wilson D, Beltrame J, Fitridge R||
Vascular Reactivity in patients with peripheral arterial disease
|MSc in Surgical Science||University of Adelaide|
|Dr Rama Ravula||2014||Fitridge R, Cowled P||Grading of Iliac artery tortuosity and calcification and its association with deployment-related complications following EVAR|
|Dr Ben Thurston||2015||Fitridge R and Cowled P||Quantification of iliac artery calcification and its influence on outcomes following endovascular abdominal aortic aneurysm repair|
|BSc Honours||University of Adelaide|
|Clementine Labrosciano||2016||Beltrame J, Fitridge R and Cowled P||Is there a relationship between Ankle Brachial Index and Health Status in patients with Peripheral Artery Disease?
Approximately 75% of lower limb amputations in Australia are associated with diabetic foot ulcers. Predisposing factors contributing to the risk of amputation are the presence and severity of infection and ischaemia, size of the ulcer and presence of osteomyelitis. The Wifi model, which takes these factors into account, has recently been developed. We aim to externally validate the Wifi model and assess what other factors are correlated with outcomes.
Up to 25% of people with diabetes will develop non-healing ulcers. Inflammation is a fundamental component of normal wound healing but excessive inflammation is a major contributing factor leading to chronic non-healing wounds. We aim to identify immune specific integrins in chronic wounds and determine whether immune specific integrin function-blocking antibodies dampen inflammation and improve healing in diabetic mouse models.
TEDY Trial: TElmisartan in the management of abDominal aortic aneurYsm (TEDY)
This trial is currently recruiting subjects who have been diagnosed with an abdominal aortic aneurysm. Small aneurysms are not usually harmful but larger ones will need surgery to avoid the aneurysm rupturing, an outcome that is frequently fatal.
The aim of the trial is to test whether administration of the blood pressure drug, telmisartan, can stop the aneurysm from becoming larger, thereby preventing the need for surgery to fix the aneurysm. Subjects will take a daily tablet of either Telmisartan or an inactive tablet every day for two years and have six monthly visits to the trial staff to monitor their health and check if the aneurysm has become any larger.
For more information contact: Professor Rob Fitridge
Barnes M, Boult M, Maddern G, Fitridge R. A model to predict outcomes for endovascular aneurysm repair using preoperative variables. Eur J Vasc Endovasc Surg; 2008. 35(5): 571-9.
Barnes M, Boult M, Thompson MM, Holt PJ, Fitridge RA. Personalised predictions of endovascular aneurysm repair success rates: validating the ERA model with UK Vascular Institute data. Eur J Vasc Endovasc Surg; 2010. 40(4): 436-41.
Dowson N, Boult M, Cowled P, De Loryn T, Fitridge R. Development of an automated measure of iliac artery tortuosity that successfully predicts early graft-related complications associated with endovascular aneurysm repair. Eur J Vasc Endovasc Surg; 2014. 48(2): 153-60.
Boult M, Howell S, Cowled P, De Loryn T, Fitridge R. Self-reported fitness of American Society of Anesthesiologists class 3 patients undergoing endovascular aneurysm repair predicts patient survival. J Vasc Surg; 2015. 62(2): 299-303.
Fitridge RA, Boult M, Mackillop C, De Loryn T, Barnes M, Cowled P, et al. International trends in patient selection for elective endovascular aneurysm repair: sicker patients with safer anatomy leading to improved 1-year survival. Ann Vasc Surg; 2015. 29(2): 197-205.
|Chief Investigators||Granting Body||Project Title||Type of Grant||Total Grant Amount||Funding Period|
|R Fitridge, M Boult, J Golledge, G Maddern, M Thompson, M Barnes||NHMRC||Evaluating a decision-making model for EVAR||Project Grant||$1,075,595||2009 - 2015|
|J Golledge, B Kingwell, P Norman, A Tonkin, R Fitridge, C Reid, P Walker, G Hankey, J Fletcher, M Nelson||NHMRC||National Centre of Research Excellence to improve management of peripheral arterial disease||Centres of Research Excellence||$2,499,250||2010 – 2014|
|J Golledge, C Rush, P Walker, R Fitridge, R Muller||NHMRC||The role of the clotting cascade in aortic aneurysm and associated cardiovascular events||Project Grant||$619,911||2011 – 2013|
|J Karnon, C Gibb, R Fitridge, V Marshall, J Field||NHMRC||Economic evaluation and optimisation of services for the preoperative assessment and management of high risk surgical patients||Project Grant||$386,155||2012 – 2014|
|J Golledge, P Norman, P Walker, A Ahimastos, R Dalman, R Fitridge||NHMRC||TElmisartan in the management of abDominal aortic aneurYsm (TEDY)||Project Grant||$1,105,893||2012 – 2016|
|PORTRAIT Registry: Patient-centered Outcomes Related to Treatment practices in peripheral Arterial disease: an International Trajectory||Prof John Beltrame||Discipline of Medicine, The University of Adelaide||Adelaide, South Australia||Australia|
|Dr John Spertus||Mid-America Heart Institute||Kansas City, Kansas||USA|
|Dr Johan Denollet||Tilburg University||Tilburg||The Netherlands|
|EVAR Trial: National and International Collaborations||Dr N Dowson||The Australian e-Health Research Centre, Computational Informatics, CSIRO and the Royal Brisbane and Womens’ Hospital||Brisbane, Queensland||Australia|
|Ms M Barnes||Mathematics, Informatics and Statistics, CSIRO||Adelaide, South Australia||Australia|
|Prof J Golledge||James Cook University||Townsville, Queensland||Australia|
|Professor M Thompson||St George’s Vascular Institute||London||UK|
|Professor R Sayers||Department of Cardiovascular Sciences, University of Leicester||Leicester||UK|
|Dr JR Boyle||Cambridge University Hospitals||Cambridge||UK|
|Dr T Forbes||Division of Vascular Surgery, London Health Sciences Centre||London, Ontario||Canada|
|TEDY Trial and Small AAA trial||Prof J Golledge||James Cook University||Townsville, Queensland||Australia|
|National Centre of Research Excellence to improve management of peripheral arterial disease||Prof J Golledge||James Cook University||Townsville, Queensland||Australia|
|Cooperative Centre for Wound Healing||Professor A Cowin||University of South Australia||Adelaide, South Australia||Australia|
|Professor N Voelcker||University of South Australia||Adelaide, South Australia||Australia|
|Steering Committee for development of the new International Standards for Vascular Care. (Society for Vascular Surgery, European Society for Vascular Surgery and World Federation of Vascular Societies)|