- Clinical Trials
The Surgical Science Research Group is led by Professor Guy Maddern, the RP Jepson Professor of Surgery at the University of Adelaide and the Director of Research at the Basil Hetzel Institute for Translational Health Research (BHI), The Queen Elizabeth Hospital (TQEH).
Our group are always looking for enthusiastic students who wish to challenge themselves and further their education through our Honours or higher degrees programs.
Dr Jaewook Oh
Dr Scott Ellis
Dr Sean Brien
Dr Nelson Granchi
Dr Paul Patiniott
Phone: (08) 8222 6000
Man Ying (Celine) Li
Student Alumni (since 2016)
|Name||Degree||Year Awarded||Thesis title||Supervisors||Scholarship|
|Dr Hannah Gostlow||MPhil (Surgery), The University of Adelaide||2018||Simulation in surgical education: lessons learned from a multi-site randomised cohort study||Maddern GJ, Babidge W||Royal Australasian College of Surgeons Scholarship|
|Joseph Smith||PhD, The University of Adelaide||2018||Surgery and climate change: The scientific and public policy implications||Maddern GJ, Hewett P||Royal Australasian College of Surgeons Scholarship|
|Helen Palethorpe||PhD, The University of Adelaide||2018, Dean's Commendation for Doctoral Thesis Excellence||Fibroblasts, Androgen Signalling and Oesophageal Adenocarcinoma||Drew P & Smith E||Faculty of Health Sciences divisional scholarship, University of Adelaide|
|Kean Kuan||MResearch, The University of Adelaide||2016||Factors influencing transplant surgery: ex vivo porcine pancreas normothermic perfusion||Maddern G, Trochsler M & Chung W|
- Development of prognostic biomarkers of metastatic colorectal cancer.
- HLA-G as predictive biomarker of response to therapy.
- Imaging biomarkers for prediction of metastatic risk in colorectal cancer patients.
- Characterisation of the immune cell compartment in liver metastasis.
- Development of targeted nanoparticles as preventative therapy for liver metastasis.
Surgery is the best chance to cure cancers in the liver. During surgery blood vessels may be clamped to control bleeding. This can lead to ischemia-reperfusion (IR) injury, which increases complications and mortality. There is no effective treatment.
In Australia there has been a recent alarming increase in men of oesophageal cancer. About 50% of patients are unsuitable for surgery at the time of diagnosis, and the five year survival is less than 15%.
Prostate cancer is the most commonly diagnosed cancer in Australia and the 4th leading cause of mortality amongst Australian males. Oesophageal adenocarcinoma is the most rapidly increasing cancer in Australia and has a male: female ratio of around 8:1.
This initiative sets out to bring together a group of experienced and practising clinicians together with an experienced translational researcher all working within the Central Adelaide Health region including the Royal Adelaide and The Queen Elizabeth Hospitals to direct research scientists working within the scope of colorectal primary and metastatic disease.
Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world, accounting for over 9% of all cancer incidences. The majority of CRC related deaths are attributable to liver metastasis (LM) – the most critical prognostic factor observed in ≈50% of CRC patients.
An estimated 9 million abdominal surgeries occur each year, with up to a staggering 95% of these resulting in the formation of intra-abdominal adhesions. The presence of adhesions may go unnoticed until clinical manifestations arise such as pain, reduced gastrointestinal function or bowel obstruction leading to the need for repeat surgical intervention.
Development of diagnostic and prognostic biomarkers for screening and early detection of metastatic colorectal cancer.
HREC reference number: HREC/14/TQEHLMH/164
For more information please contact: Dr Kevin Fenix
|Chief Investigators||Granting body||Project Title||Type of Grant||Total Grant Amount||Funding Period|
|Richter K||NHMRC #1163634||Maximising the effectiveness of antimicrobial treatments for infection control after surgery||NHMRC CJ Martin Biomedical Early Career Fellowship||$417,192||2019 - 2022|
|Karatassas A||Royal Australasian College of Surgeons (RACS) Foundation for Surgery||Developing a hernia mesh tissue integrated index||Small Project Grant||$10,000||2019|
|Fenix K||The Hospital Research Foundation (THRF)||Using tissue-resident T cells to develop new prognostics and treatments against bowel cancer||THRF Early Career Fellowship||$240,000||2018 - 2020|
|Wormald PJ, Maddern G, Vreugde S||The Hospital Research Foundation (THRF)||A novel medicated resorbable adhesion barrier device for use in abdominal surgery||Development Grant||$75,000||2018 - 2020|
|Dhakal B||Schlumberger Foundation||The immune cell compartment in colorectal liver metastasis||Faculty for the Future Fellowship (International PhD Scholarship)||US$150,000||2018 - 2020|
|Richter K||The Hospital Research Foundation (THRF)||Improving effectiveness of infection control after surgery||THRF Early Career Fellowship||$240,000||2018 - 2020|
|Maddern G, Price T, Young J, Hewett P, Hardingham J, Worthley D, White D, Mulligan D||SAHMRI/BEAT Cancer/The Hospital Research Foundation||Individualised risk assessment and therapeutic interventional for colorectal cancer in the South Australian population||Project Grant||$750,000||2014 - 2019|
|Maddern G, Trochsler M, Tivey D, Vreugdeburg T||Federal Office of Public Health, Health and Accident Insurance, Benefits, Department of Health Technology Assessment, Switzerland||Health Technology Assessment Framework Agreement||Project Grant||$2,800,000||2018 - 2019|
|Ma L, Liang Q, Hauben E, Fenix K||Flinders Innovation Partnership Seed Grants Scheme||Study of bioactivity of Hengshan Astragalus Shiitake as biological response modifiers in cancer therapy||Seed Grant||$125,000||2018 - 2019|
|Richter K||The University of Adelaide||Ironing out superbugs - validation and translation of a novel treatment that kills antibiotic-resistant bacteria by targeting iron metabolism||Early Career Research Fellowship||$120,000||2018|
|Richter K||The Hospital Research Foundation (THRF)||Ironing out superbugs - validation and translation of a novel treatment that kills antibiotic-resistant bacteria by targeting iron metabolism||Leverage Funding |
- Early Career Research Fellowship
|Maddern G||The Hospital Research Foundation (THRF)||A comprehensive video-based coaching program for continuing surgical improvement - design, efficacy assessment and clinical implementation||Project Grant||$84,000||2018|
|Eldredge TA||Royal Australasian College of Surgeons (RACS)||Bile reflux post-bariatric surgery - a cohort study||RP Jepson Scholarship||$66,000||2018|
|Ludbrook G, Walsh R, Story D, Maddern G||Australian and New Zealand College of Anaesthetists (ANZCA)||Extended post-anaesthesia care - a feasibility study||Elaine Lillian Kluver ANZCA Research Award||$69,994||2018|
|Kopecki Z, Grubor-Bauk B, Wijesundara D, Fenix K||University of South Australia||Identify a diagnostic marker for psoriasis||New Adventures Fund||$18,193||2018|
|Gowans E, Wijesundara D, Maddern G||The Hospital Research Foundation (THRF)||The protective efficacy of cytolytic DNA vaccine for HCV in marmosets: a step forward towards human clinical trials||Development Grant||$200,000||2017 - 2018|
|Hauben E, Voelcker N, Maddern G||The Hospital Research Foundation (THRF)||Development of targeted nanoparticles as preventative therapy for liver metastasis||Project Grant||$125,000||2017 - 2018|
|Maddern G, Hauben H, Ngo D, Beltrame J||The Hospital Research Foundation (THRF)||The nexus between visceral adiposity, associated liver composition, and metastatic progression in colorectal cancer patients||Project Grant||$75,000||2016|
|Hauben E, Gowans E, Vreugde S, Evdokiou A, Maddern G||ARC Linkage, Infrastructure, Equipment and Facilities (LIEF) grant||Miltenyi AutoMACS Pro||Equipment grant||$30,000||2016|
|Maddern GJ, Roberts M, Crawford D||NHMRC||Advanced imaging to define hepatic and intestinal drug disposition in aging and liver disease||Project Grant||$735,820||2013 - 2015|
|Maddern GJ, Runciman W, Mandel C, Schultz T, Munn Z||HCF Health and Medical Research Foundation||Use of surgical and radiology checklists in Australian hospitals: uptake, barriers and enablers||$311,195||2013 - 2015|
|Maddern GJ, Wormald PJ, S Moratti S, Robinson B, Robinson S||NHMRC||In vivo evaluation of the safety and efficacy of a novel chitosan gel in the reduction of adhesions following abdominal surgery in both animal and human models||Project Grant||$514,975||2013 - 2015|
|Rogers WA, Johnson AJ, Townley C, Sheridan J, Ballantyune A, Lotz M, Meyerson D, Tomosey GF, Eyers AA, Maddern GJ, Thomson CJ||ARC||On the cutting edge: promoting|
best practice in surgical innovation
|Linkage Grant||$255,000||2011 - 2014|
|Maddern GJ, Fitridge R, Boult M, Golledge J, Thompson M, Barnes M||NHMRC||Prospective evaluation of a model to predict outcomes following endovascular aortic aneurysm repair||Project Grant||$1,036,925||2009 - 2013|
|Maddern GJ, Wormald PJ, Jamieson G, Fitridge R, Hewett P||The Hospital Research Foundation (THRF)||Development and assessment of novel surgical technologies and their introduction into the Australian healthcare system||Program Grant||$1,250,000||2009 - 2013|
|Professor Ashley Dennison, MBChB, MD, FRCS||Consultant Hepatobiliary and Pancreatic Surgeon||University Hospitals of Leicester||Leicester||United Kingdom|
|Professor Richard Stubbs, MD, FRCS, FRACS||Consultant Surgeon & Director||The Wakefield Clinic||Wellington||New Zealand|
|Professor Jun Feng Liu||Head, Department of Thoracic Surgery||Fourth Hospital, Hebei Medical University||Shijiazhuang||China|
|Associate Professor Timothy Underwood||Consultant Upper GI surgeon||University of Southampton & University Hospital Southampton||Southampton||United Kingdom|
|Professor Nico Voelcker||Scientific Director of Melbourne Centre for Nanofabrication, Director of the Australian National Fabrication Facility's Victorian Node (ANFF-VIC), Science Leader at CSIRO and Professor||Monash Institute of Pharmaceutical Sciences, Monash University||Melbourne||Australia|
|Dr Lifeng Peng||Researcher, Course Coordinator and Lecturer||Proteomics, School of Biological Sciences, Victoria University of Wellington||Wellington||New Zealand|